CDC14B
Chr 9cell division cycle 14B
Also known as: CDC14B3, Cdc14B1, Cdc14B2, hCDC14B
This dual-specificity phosphatase regulates the G2 DNA damage checkpoint by dephosphorylating key cell cycle proteins including FZR1/CDH1 and tumor suppressor p53, preventing entry into mitosis following DNA damage. The gene is highly constrained against loss-of-function variants, but no established Mendelian diseases have been associated with CDC14B mutations to date. Further research is needed to determine if pathogenic variants in this gene cause human disease.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly LoF-intolerant (top ~10% of genes)
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
CDC14B · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools