CD7
Chr 17CD7 molecule
Also known as: GP40, LEU-9, TP41, Tp40
This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development. [provided by RefSeq, Jul 2008]
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Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
ClinVar Variant Classifications
83 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 0 | 0 | 19 | 0 | 19 |
Likely Pathogenic | 0 | 0 | 3 | 0 | 3 |
VUS | 0 | 41 | 9 | 0 | 50 |
Likely Benign | 0 | 9 | 1 | 1 | 11 |
Benign | 0 | 0 | 0 | 0 | 0 |
| Total | 0 | 50 | 32 | 1 | 83 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
CD7 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
OMIM — Genotype-Phenotype Relationships
1 OMIM entry
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
Cell Therapy for High Risk T-Cell Malignancies Using CD7-Specific CAR Expressed On Autologous T Cells
RECRUITINGAnti-CD7 CAR-T Cells in Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia or Lymphoma
RECRUITINGGenomic Analysis to Identify a Predictive Biomarker for Immunotherapy
RECRUITINGStudy of Autophagy and the Effects of GALIG Gene Products in HIV-1 Infected Patients Who Are Under Antiretroviral Therapy Since Primary-infection, Chronic Phase, or Never Treated.
RECRUITINGEvaluation of the KIR3DL2 Marker in Flow Cytometry for Sézary Syndrome Diagnosis, Therapeutic Response and Residual Disease: a Prospective and Multicenter Study
NOT YET RECRUITINGA Clinical Study of CAR-T Treating Relapsed or Refractory T Cell Lymphoblastic Acute Leukemia/ Lymphoma
ACTIVE NOT RECRUITINGPredicting IBD Treatment Outcomes With Gut Microbiome Analysis
RECRUITINGClinical Study on the Safety and Efficacy of CD7-Targeted Chimeric Antigen Receptor (CAR) Gene-Modified T Cells for the Treatment of CD7-Positive Hematological Malignancies
NOT YET RECRUITINGCD7-CAR-T Cells in Pediatric Relapsed/Refractory CD7+ T-ALL/LL
RECRUITINGUniversal 4SCAR7U Targeting CD7-positive Malignancies
RECRUITINGObservatory of Prolymphocytic Leukemia T
RECRUITINGExternal Resources
Links to major genomics databases and tools