CD63
Chr 12CD63 molecule
Also known as: AD1, HOP-26, ME491, MLA1, OMA81H, Pltgp40, TSPAN30
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
CD63 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
Training Induced Muscle-Adipose EV Communication
NOT YET RECRUITINGSystems Investigation of Vaccine Responses in Aging and Frailty
RECRUITINGImpact of Diet and Lifestyle Modification on the Intestinal Barrier Integrity in Crohn's Disease
RECRUITINGExternal Resources
Links to major genomics databases and tools