CD200R1L

Chr 3

CD200 receptor 1 like

Also known as: CD200R2, CD200RLa

NCBI Gene: 344807ENSG00000206531UniProt: Q6Q8B3

Predicted to enable signaling receptor activity. Predicted to be involved in regulation of neuroinflammatory response. Predicted to be located in cell surface and membrane. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
0
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.94
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.94LOEUF
pLI 0.003
Z-score 1.73
OE 0.47 (0.26–0.94)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
-0.41Z-score
OE missense 1.10 (0.96–1.25)
160 obs / 145.9 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.47 (0.26–0.94)
0≤0.351.4
Missense OE?1.10 (0.96–1.25)
0≤0.61.4
Synonymous OE?1.32
0≤1.21.6
LoF obs/exp: 6 / 12.6Missense obs/exp: 160 / 145.9Syn Z: -1.86

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

CD200R1L · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients