CD163

Chr 12

CD163 molecule

Also known as: M130, MM130, SCARI1

NCBI Gene: 9332ENSG00000177575UniProt: Q86VB7OMIM: 605545

The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

OMIMResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant
This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.
12
Active trials
1313
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.44
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Moderate LoF intolerance
LoF Constraint?
0.44LOEUF
pLI 0.001
Z-score 4.95
OE 0.30 (0.20–0.44)
Moderately constrained

More LoF-intolerant than ~75% of genes

Missense Constraint?
2.51Z-score
OE missense 0.72 (0.67–0.78)
455 obs / 632.6 exp
Mild constraint

Moderately missense-constrained (top ~2.5%)

Observed / Expected Ratios?
LoF OE?0.30 (0.20–0.44)
0≤0.351.4
Missense OE?0.72 (0.67–0.78)
0≤0.61.4
Synonymous OE?0.97
0≤1.21.6
LoF obs/exp: 17 / 57.6Missense obs/exp: 455 / 632.6Syn Z: 0.33

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

CD163 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov
Oral LeukoplakiaOral Leukoplakia of TongueOral Leukoplakia of Gingiva

Prediction of Malignant Transformation of Oral Leukoplakia Using a MAGE-A-based Immunoscore

RECRUITING
NCT03975322University of Erlangen-Nürnberg Medical SchoolStarted 2019-12-01
Environmental Enteric Dysfunction (EED)

Maternal Probiotic Intervention to Improve Gut Health - Trial II - Burkina Faso (MPIGH-II)

RECRUITING
NCT07134790Phase PHASE2University GhentStarted 2025-07-30
VE818PlaceboOral Vancomycin
Systemic Sclerosis (SSc)

Tissue Modeling in Systemic Sclerosis Using Induced Pluripotent Stem Cells (iPSCs)

NOT YET RECRUITING
NCT07650565Phase NAUniversity Hospital, MontpellierStarted 2026-09
Blood Sample Collection
Chronic Kidney Diseases

Dapagliflozin on Renal Morphology and Renal Perfusion in Patients One Year After Kidney Transplantation

RECRUITING
NCT06560801Phase PHASE4University of Erlangen-Nürnberg Medical SchoolStarted 2023-07-28
Dapagliflozin 10mg Tab
HealthyObesity

A Study of Adipose Tissue in Adaptive Responses to Exercise

ACTIVE NOT RECRUITING
NCT06053125Phase NAMayo ClinicStarted 2023-11-09
Adipose Tissue BiopsyExercise
Obstructive Sleep Apnea-Hypopnea SyndromeAnxiety DisordersDepressive Disorders

EGR2 and NLRP3 Pathways in Obstructive Sleep Apnea-Related Cognitive and Mood Disorders

RECRUITING
NCT07120711Xinhua Hospital, Shanghai Jiao Tong University School of MedicineStarted 2025-07-01
EGR2/NLRP3 pathway activityfatty tissue
Crohn Disease (CD)

The Microbial Impact on Intestinal Fibrosis and the Associated Immune Microenvironment in Crohn's Disease

NOT YET RECRUITING
NCT06720961IRCCS San RaffaeleStarted 2025-04
Collection of surgical specimenCollection of stool sample
Time Restricted EatingObesityWeight Loss

Time-restricted Eating Versus Daily Continuous Calorie Restriction on Body Weight and Colorectal Cancer Risk Markers

ACTIVE NOT RECRUITING
NCT05114798Phase NAUniversity of Illinois at ChicagoStarted 2022-05-17
Time restricted eatingCalorie Restriction
Psoriasis VulgarisPsoriasisSkin Diseases

Residual Disease MEMory in PSOriasis Skin During EnstiLAR® and Narrow-band Ultraviolet B Therapy: The MEMPSOLAR Study

ACTIVE NOT RECRUITING
NCT05185258Phase PHASE4Aarhus University HospitalStarted 2022-02-16
EnstilarPlacebo-vehicle
Environmental Enteric Dysfunction (EED)Stunting

Maternal Probiotic Intervention to Improve Gut Health-Trial II-Pakistan

RECRUITING
NCT07207434Phase PHASE2Aga Khan UniversityStarted 2025-08-30
Oral VancomycinVE818Placebo
Environmental Enteric Dysfunction

Maternal Probiotic Intervention to Improve Gut Health - Trial II - Bangladesh

ENROLLING BY INVITATION
NCT06817031Phase PHASE2International Centre for Diarrhoeal Disease Research, BangladeshStarted 2025-04-20
VE818PlaceboOral Vancomycin
HealthyHealthy Nutrition

The BEGIN Study Bifidobacterium Infantis to Newborns: Effects of Modulating the Gut Microbial Composition on Growth, Immune Function and Inflammatory Conditions - a Randomized Placebo-controlled Double-blinded Intervention Trial

RECRUITING
NCT06452199Phase NAUniversity of AarhusStarted 2024-06-10
B. infantisPlacebo

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients