CCP110
Chr 16centriolar coiled-coil protein 110
Also known as: CP110, Cep110
CCP110 encodes a protein necessary for centrosome duplication and acts as a key negative regulator of ciliogenesis by capping the mother centriole to prevent cilia formation, while also being required for correct spindle formation and cytokinesis regulation. The gene is highly constrained against loss-of-function variants (LOEUF 0.454), suggesting that mutations are likely to cause severe developmental phenotypes. Pathogenic variants are expected to follow an autosomal dominant inheritance pattern given the gene's critical cellular functions and constraint metrics.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
CCP110 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools