CCNYL1
Chr 2cyclin Y like 1
CCNYL1 encodes a key regulator of Wnt signaling that activates cyclin-dependent kinase CDK16 and is essential for sperm maturation, embryonic neurogenesis, and cortical development. The gene is highly constrained against loss-of-function variants (LOEUF 0.494), but no definitive human disease associations have been established in the provided data. Given its role in neurogenesis and cortical development, mutations would likely affect brain development and male fertility.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
CCNYL1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools