CCNB2

Chr 15

cyclin B2

Also known as: HsT17299

NCBI Gene: 9133 ENSG00000157456 UniProt: O95067 OMIM: 602755

Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008]

OMIM Research

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

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LOEUF

Mechanism· predicted

Some data sources returned errors (1)

gnomad: Error: gnomAD API error: 400

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

Background carrier burden — how many people carry a rare variant somewhere in CCNB2?

gnomAD v4 · ~731k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 130

533 rare PASS variants

Rare truncating (LoF)

1 in 2,000

94 rare PASS variants

Rare synonymous (reference)

1 in 180

194 rare PASS variants

Truncating variants are far rarer here than missense — that gap, in human units, is what constraint means for CCNB2. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~556k	1 in 190	1 in 2,000
South Asian	~43k	1 in 100	1 in 2,500
Remaining (unassigned)	~30k	1 in 110	1 in 430
European (Finnish)	~27k	1 in 590	≈ 1 in 27,000
Admixed American	~22k	1 in 86	1 in 1,600
African / African American	~21k	1 in 100	1 in 1,600
East Asian	~20k	1 in 150	1 in 1,400
Ashkenazi Jewish	~13k	1 in 920	1 in 2,600
Middle Eastern	~2,884	1 in 160	≈ 1 in 1,400

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.

Exome coverage (gnomAD): All 9 coding exons well covered in gnomAD exomes and genomes.? see exons ↓