CCL27

Chr 9

C-C motif chemokine ligand 27

Also known as: ALP, CTACK, CTAK, ESKINE, ILC, PESKY, SCYA27

NCBI Gene: 10850 ENSG00000213927 UniProt: Q9Y4X3

The protein is a chemokine that attracts skin-associated memory T lymphocytes to cutaneous sites by binding to the CCR10 receptor. Mutations in CCL27 cause autosomal dominant atopic dermatitis-like eruption, affecting the skin and immune system. The gene is not highly constrained against loss-of-function variants, suggesting tolerance to functional disruption.

ResearchSummary from RefSeq, UniProt

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

1.65

LOEUF

Mechanism· predicted

Some data sources returned errors (1)

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