CCL27

Chr 9

C-C motif chemokine ligand 27

Also known as: ALP, CTACK, CTAK, ESKINE, ILC, PESKY, SCYA27

NCBI Gene: 10850ENSG00000213927UniProt: Q9Y4X3

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014]

96
ClinVar variants
70
Pathogenic / LP
0.01
pLI score
1
Active trials
Clinical Summary— CCL27
⚡
Population Constraint (gnomAD)
Low constraint (pLI 0.01) — loss-of-function variants are relatively tolerated in the population.
📋
ClinVar Variants
70 Pathogenic / Likely Pathogenic· 25 VUS of 96 total submissions
💊
Clinical Trials
1 active or recruiting trial — potential therapeutic options may be available

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?LOEUF (Loss-of-function Observed/Expected Upper bound Fraction) is the upper bound of the 90% CI for LoF OE — the preferred gnomAD v4 metric. Lower = more intolerant to LoF. LOEUF < 0.35 = highly constrained.
1.65LOEUF
pLI 0.014
Z-score 0.58
OE 0.70 (0.32–1.65)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?Missense Z-score: standard deviations fewer missense variants observed vs. expected. Z > 3.09 (p < 0.001) = gene does not tolerate missense variation. OE missense < 0.6 is also considered constrained.
0.41Z-score
OE missense 0.85 (0.68–1.08)
50 obs / 58.8 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?Shaded band = 90% confidence interval. Vertical tick = point estimate. Grey threshold line = gnomAD constraint cutoff for that variant class.
LoF OE?Ratio of observed to expected LoF variants. Upper CI bound (LOEUF) ≤ 0.35 = strong LoF constraint signal.0.70 (0.32–1.65)
0≤0.351.4
Missense OE?Ratio of observed to expected missense variants. OE ≤ 0.6 = fewer missense variants than expected by chance.0.85 (0.68–1.08)
0≤0.61.4
Synonymous OE?Control metric — synonymous variants are largely neutral and expected near OE = 1.0. Significant deviation may indicate annotation issues.0.96
0≤1.21.6
LoF obs/exp: 3 / 4.3Missense obs/exp: 50 / 58.8Syn Z: 0.17

ClinVar Variant Classifications

96 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic62
Likely Pathogenic8
VUS25
Benign1
62
Pathogenic
8
Likely Pathogenic
25
VUS
1
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
0
0
62
0
62
Likely Pathogenic
0
0
8
0
8
VUS
0
14
11
0
25
Likely Benign
0
0
0
0
0
Benign
0
1
0
0
1
Total01581096

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

CCL27 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Biomarkers in atopic dermatitis-a review on behalf of the International Eczema Council.
Renert-Yuval Y et al.·J Allergy Clin Immunol
2021Review
Single-cell transcriptomics applied to emigrating cells from psoriasis elucidate pathogenic versus regulatory immune cell subsets.
Kim J et al.·J Allergy Clin Immunol
2021
NOS2 and CCL27: clinical implications for psoriasis and eczema diagnosis and management.
Garzorz N et al.·Expert Rev Clin Immunol
2015Review
The neglected twin: Nummular eczema is a variant of atopic dermatitis with codominant T(H)2/T(H)17 immune response.
Böhner A et al.·J Allergy Clin Immunol
2023
Nucleus pulposus cells regulate macrophages in degenerated intervertebral discs via the integrated stress response-mediated CCL2/7-CCR2 signaling pathway.
Tian S et al.·Exp Mol Med
2024
Serum CCL27 predicts the response to Bacillus Calmette-Guerin immunotherapy in non-muscle-invasive bladder cancer.
Zhong W et al.·Oncoimmunology
2020
Correlation analysis between IL-35, IL-36γ, CCL27 and psoriasis vulgaris.
Chen J et al.·J Dermatolog Treat
2021
Large-Scale Blood Proteomic Analysis Across Different Inflammatory Skin Conditions Reveals Extensive Immune Dysregulation With Distinct Biomarker Profiles.
Glickman JW et al.·Allergy
2026
Blocking of IL-4/IL-13 Signalling With Dupilumab Results in Restoration of Serum and Cutaneous Abnormalities in Netherton Syndrome.
Blunder S et al.·Exp Dermatol
2025
CTACK /CCL27 expression in psoriatic skin and its modification after administration of etanercept.
Campanati A et al.·Br J Dermatol
2007Clinical trial
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov
Aging

Effect of Snacks on Aging

RECRUITING
NCT06879626Phase NAUniversity of California, Los AngelesStarted 2025-05-19
PecanPretzel

External Resources

Links to major genomics databases and tools