CCL22

Chr 16

C-C motif chemokine ligand 22

Also known as: A-152E5.1, ABCD-1, DC/B-CK, MDC, SCYA22, STCP-1

NCBI Gene: 6367 ENSG00000102962 UniProt: O00626 OMIM: 602957

The protein encoded by this gene is a chemokine that attracts monocytes, dendritic cells, natural killer cells, and activated T lymphocytes to inflammatory sites by binding to the CCR4 receptor. The gene shows low constraint to loss-of-function variation (pLI = 0.008, LOEUF = 1.8), suggesting it may tolerate complete loss of function. No established Mendelian diseases have been associated with CCL22 mutations in current databases.

OMIM ResearchSummary from RefSeq, UniProt

This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. [provided by RefSeq, Sep 2014]

OMIM ResearchGenerating clinical summary…

Active trials

177

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

—

LOEUF

Mechanism· predicted

Some data sources returned errors (1)