CCL17

Chr 16

C-C motif chemokine ligand 17

Also known as: A-152E5.3, ABCD-2, SCYA17, TARC

NCBI Gene: 6361ENSG00000102970UniProt: Q92583

This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Sep 2014]

ResearchGenerating clinical summary…
3
Active trials
215
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.92
LOEUF
DN
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.92LOEUF
pLI 0.000
Z-score -0.70
OE 1.40 (0.67–1.92)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.48Z-score
OE missense 0.81 (0.64–1.05)
42 obs / 51.6 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?1.40 (0.67–1.92)
0≤0.351.4
Missense OE?0.81 (0.64–1.05)
0≤0.61.4
Synonymous OE?0.69
0≤1.21.6
LoF obs/exp: 5 / 3.6Missense obs/exp: 42 / 51.6Syn Z: 1.12

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

CCL17 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients