CASC15

Chr 6

cancer susceptibility 15

Also known as: CANT, LINC00340, lnc-SOX4-1

NCBI Gene: 401237ENSG00000272168

This gene produces a long non-coding RNA that may regulate cell proliferation. This RNA is upregulated in hepatocellular carcinoma, where it is thought to function as an oncogene. However, some splice variants of this gene may function as a tumor suppressor in neuroblastoma and other tumor types. Circular RNA variants were observed at this gene. [provided by RefSeq, Dec 2017]

4
ClinVar variants
3
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— CASC15
📋
ClinVar Variants
3 Pathogenic / Likely Pathogenic· 1 VUS of 4 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

4 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic3
VUS1
3
Pathogenic
1
VUS

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————3
Likely Pathogenic
————0
VUS
————1
Likely Benign
————0
Benign
————0
Total—4

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

CASC15 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
The dual functions of the long noncoding RNA CASC15 in malignancy.
Gu X et al.·Biomed Pharmacother
2021Review
A study of the prognostic value of long non-coding RNA CASC15 in human solid tumors utilizing The Cancer Genome Atlas (TCGA) datasets and a meta-analysis.
Chen W et al.·Clin Exp Med
2023Meta-analysis
LncRNA CASC15 promotes colon cancer cell proliferation and metastasis by regulating the miR‑4310/LGR5/Wnt/β‑catenin signaling pathway.
Jing N et al.·Mol Med Rep
2018
Hypoxia-sensitive long noncoding RNA CASC15 promotes lung tumorigenesis by regulating the SOX4/β-catenin axis.
Sun J et al.·J Exp Clin Cancer Res
2021
Exploring the mechanism of LncRNA CASC15 affecting hepatocellular carcinoma through miRNA.
Cai Q et al.·Medicine (Baltimore)
2024Functional
[Clinical Significance of Low Expression of LncRNA CASC15 in Acute Myeloid Leukemia with NPM1 Mutations].
Xia PH et al.·Zhongguo Shi Yan Xue Ye Xue Za Zhi
2022
Immunological microenvironment differences between left and right colon cancer: dynamic interactions of CASC15+KLK6+ epithelial subpopulation with T cells and mast cells.
Zhao Y et al.·Int J Surg
2026
Long Non-coding RNA CASC15 Promotes Intrahepatic Cholangiocarcinoma Possibly through Inducing PRDX2/PI3K/AKT Axis.
Zhang Y et al.·Cancer Res Treat
2021
Long non-coding RNA CASC15 is upregulated in hepatocellular carcinoma and facilitates hepatocarcinogenesis.
He T et al.·Int J Oncol
2017
The CASC15 Long Intergenic Noncoding RNA Locus Is Involved in Melanoma Progression and Phenotype Switching.
Lessard L et al.·J Invest Dermatol
2015
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools