CARMN

Chr 5

cardiac mesoderm enhancer-associated non-coding RNA

Also known as: CARMEN, MIR143HG

NCBI Gene: 728264ENSG00000249669

Predicted to be involved in regulation of gene expression. Predicted to be part of RISC complex. Biomarker of atherosclerosis. [provided by Alliance of Genome Resources, Jul 2025]

5
ClinVar variants
4
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— CARMN
📋
ClinVar Variants
4 Pathogenic / Likely Pathogenic· 1 VUS of 5 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

5 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic4
VUS1
4
Pathogenic
1
VUS

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
0
0
4
0
4
Likely Pathogenic
0
0
0
0
0
VUS
0
0
1
0
1
Likely Benign
0
0
0
0
0
Benign
0
0
0
0
0
Total00505

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

CARMN · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
CARMN Is an Evolutionarily Conserved Smooth Muscle Cell-Specific LncRNA That Maintains Contractile Phenotype by Binding Myocardin.
Dong K et al.·Circulation
2021
The Long Noncoding RNA Cardiac Mesoderm Enhancer-Associated Noncoding RNA (Carmn) Is a Critical Regulator of Gastrointestinal Smooth Muscle Contractile Function and Motility.
He X et al.·Gastroenterology
2023
LncRNA CARMN inhibits abdominal aortic aneurysm formation and vascular smooth muscle cell phenotypic transformation by interacting with SRF.
Liu S et al.·Cell Mol Life Sci
2024
Expanding the Spectrum of NR4A3 Fusion-Positive Gynecologic Leiomyosarcomas.
Momeni-Boroujeni A et al.·Mod Pathol
2024
LncRNA CARMN inhibits cervical cancer cell growth via the miR-92a-3p/BTG2/Wnt/β-catenin axis.
Wang L et al.·Physiol Genomics
2023
Exploring the Spectrum of Long Non-Coding RNA CARMN in Physiological and Pathological Contexts.
Li H et al.·Biomolecules
2024Review
CARMN-NOTCH2 fusion transcript drives high NOTCH2 expression in glomus tumors of the upper digestive tract.
Girard N et al.·Genes Chromosomes Cancer
2021
Long Noncoding RNAs CARMN, LUCAT1, SMILR, and MALAT1 in Thoracic Aortic Aneurysm: Validation of Biomarkers in Clinical Samples.
Patamsytė V et al.·Dis Markers
2020
Detection of cell-type-enriched long noncoding RNAs in atherosclerosis using single-cell techniques: A brief review.
Wu Z et al.·Life Sci
2023Review
Gastroesophageal Glomus Tumors: Clinicopathologic and Molecular Genetic Analysis of 26 Cases With a Proposal for Malignancy Criteria.
Papke DJ Jr et al.·Am J Surg Pathol
2022Cohort
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
CARMN loss promotes VSMC-derived foam cell formation and atherosclerosis through transcriptional downregulation of autophagy.
Huang T et al.·Cell Death Dis
2025🔓 Open Access
CARMN orchestrates angiogenesis from behind the opera scenes: signing love letters to the endothelium.
Pande S et al.·J Clin Invest
2025🔓 Open Access
Malignant Glomus Tumor of the Uterus With Cyclin D1 Expression and CARMN::NOTCH2 Fusion.
Li F et al.·Int J Gynecol Pathol
2025
The roles of LncRNA CARMN in cancers: biomarker potential, therapeutic targeting, and immune response.
Liu H et al.·Discov Oncol
2024🔓 Open Access
Transcriptional and post-transcriptional regulation of CARMN and its anti-tumor function in cervical cancer through autophagic flux blockade and MAPK cascade inhibition.
Zhang X et al.·J Exp Clin Cancer Res
2024🔓 Open Access
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools