CAPN6
Chr Xcalpain 6
Also known as: CANPX, CAPNX, CalpM, DJ914P14.1
CAPN6 encodes a proteolytically inactive member of the calcium-dependent cysteine protease family that functions as a microtubule-stabilizing protein and regulates cytoskeletal organization and cell mobility through RAC1 signaling pathways. The gene is highly constrained against loss-of-function variants, but specific disease associations and inheritance patterns have not been established in the provided data.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
CAPN6 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools