Ensembl is currently experiencing issues

The Ensembl REST API is temporarily unavailable. Some gene data (transcript details, protein domains) may be incomplete. Other data sources are unaffected.

You can check Ensembl's status at status.ensembl.org

CAMRQ1

Chr 9AR

very low density lipoprotein receptor

Also known as: CAMRQ1, CARMQ1, CHRMQ1, VLDL-R, VLDLRCH

The very low density lipoprotein receptor (VLDLR) is a cell surface receptor that mediates endocytosis of VLDL triglycerides and functions in the reelin signaling pathway important for brain development. Biallelic mutations cause cerebellar hypoplasia with impaired intellectual development and dysequilibrium syndrome, characterized by cerebellar underdevelopment and balance problems. This condition follows autosomal recessive inheritance.

GeneReviewsOMIMResearchSummary from RefSeq, OMIM
AR1 OMIM phenotype
Clinical SummaryCAMRQ1
💊
Clinical Trials
3 active or recruiting trials — potential therapeutic options may be available
📖
GeneReview available — CAMRQ1
Authoritative clinical overview · Recommended first read
Open GeneReview ↗
Some data sources returned errors (2)

ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/CAMRQ1?content-type=application/json&expand=1

gnomad: Error: Gene not found

Population Genetics & Constraint

Constraint data not available from gnomAD.

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

CAMRQ1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold
Clinical Literature
Open Research Assistant →
Key Publications
Landmark & review papers · by relevance
PubMed
Top 2 results · since 2015Search PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC

No open access results found