CALML3

Chr 10

calmodulin like 3

Also known as: CLP

NCBI Gene: 810ENSG00000178363UniProt: P27482

Predicted to enable calcium ion binding activity. Predicted to be involved in calcineurin-mediated signaling; detection of calcium ion; and regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…
0
Active trials
10
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.90
LOEUF
DN
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.90LOEUF
pLI 0.001
Z-score -0.43
OE 1.26 (0.57–1.90)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.94Z-score
OE missense 0.76 (0.64–0.90)
90 obs / 118.7 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?1.26 (0.57–1.90)
0≤0.351.4
Missense OE?0.76 (0.64–0.90)
0≤0.61.4
Synonymous OE?0.82
0≤1.21.6
LoF obs/exp: 4 / 3.2Missense obs/exp: 90 / 118.7Syn Z: 1.05

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

CALML3 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients