CALHM6

Chr 6

calcium homeostasis modulator family member 6

Also known as: C6orf187, FAM26F, INAM, dJ93H18.5

Predicted to enable monoatomic cation channel activity. Predicted to be involved in ATP export; monoatomic cation transmembrane transport; and regulation of natural killer cell cytokine production. Predicted to be located in immunological synapse. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
2
Active trials
4
Pubs (1 yr)
P/LP submissions
P/LP missense
1.77
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.77LOEUF
pLI 0.009
Z-score 0.31
OE 0.82 (0.361.77)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.19Z-score
OE missense 0.95 (0.821.10)
128 obs / 134.3 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.82 (0.361.77)
00.351.4
Missense OE?0.95 (0.821.10)
00.61.4
Synonymous OE?0.88
01.21.6
LoF obs/exp: 3 / 3.6Missense obs/exp: 128 / 134.3Syn Z: 0.74

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

CALHM6 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.