C9ORF50

Chr 9

chromosome 9 open reading frame 50

The C9ORF50 protein is located in the cytoplasm, but its specific function remains poorly characterized. This gene is not well-constrained against loss-of-function variants and currently lacks established disease associations in pediatric neurology. Further research is needed to determine its clinical relevance.

ResearchSummary from RefSeq
LOEUF 1.38
Clinical SummaryC9ORF50
Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.
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Clinical Trials
1 active or recruiting trial — potential therapeutic options may be available

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint
1.38LOEUF
pLI 0.000
Z-score 0.48
OE 0.87 (0.561.38)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint
0.79Z-score
OE missense 0.84 (0.740.96)
164 obs / 194.9 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios
LoF OE0.87 (0.561.38)
00.351.4
Missense OE0.84 (0.740.96)
00.61.4
Synonymous OE0.86
01.21.6
LoF obs/exp: 13 / 15.0Missense obs/exp: 164 / 194.9Syn Z: 1.02

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

C9ORF50 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold
Clinical Literature
Open Research Assistant →
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC