C9ORF153
Chr 9chromosome 9 open reading frame 153
Also known as: bA507D14.1
I cannot provide a clinical gene summary for C9ORF153 as no information about the protein's function, associated diseases, inheritance patterns, or pathogenic mechanisms was provided in the data. The gene appears to be tolerant of loss-of-function variants based on the low pLI score and high LOEUF value, but this alone is insufficient to generate a meaningful clinical summary for child neurologists.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
C9ORF153 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools