C4ORF33
Chr 4chromosome 4 open reading frame 33
Clinical Summary— C4ORF33
⚡
Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Tolerant — LoF & missense variants common in population
LoF Constraint
1.34LOEUF
pLI 0.000
Z-score 0.78
OE 0.74 (0.44–1.34)
Highly tolerant — LoF variants common in population
Missense Constraint
-0.07Z-score
OE missense 1.02 (0.87–1.21)
99 obs / 97.0 exp
Tolerant to missense variation
Observed / Expected Ratios
LoF OE0.74 (0.44–1.34)
0≤0.351.4
Missense OE1.02 (0.87–1.21)
0≤0.61.4
Synonymous OE0.82
0≤1.21.6
LoF obs/exp: 8 / 10.7Missense obs/exp: 99 / 97.0Syn Z: 0.83
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
C4ORF33 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →Clinical Literature
Open Research Assistant →Landmark / reviewRecent case evidence
Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
Associations between Gene-Gene Interaction and Overweight/Obesity of 12-Month-Old Chinese Infants
Mei H et al.·Biomed Res Int
2022
Transgelin: a new gene involved in LDL endocytosis identified by a genome-wide CRISPR-Cas9 screen
Lucero D et al.·J Lipid Res
2022
Impact of 5HydroxyMethylCytosine (5hmC) on reverse/direct association of cell-cycle, apoptosis, and extracellular matrix pathways in gastrointestinal cancers
Moravveji SS et al.·BMC Genom Data
2022
Chitinase 3-like 1 is neurotoxic in multiple sclerosis patient-derived cortical neurons
Pinteac R et al.·Clin Transl Med
2024
Paleozoic Protein Fossils Illuminate the Evolution of Vertebrate Genomes and Transposable Elements
Frith MC·Mol Biol Evol
2022
Top 5 full-text resultsSearch PubTator3 ↗
Key Publications
Landmark & review papers · by relevance
A genome-wide association study of adults with community-acquired pneumonia.
Suarez-Pajes E et al.·Respir Res
2024
A Tiered Approach to Exome Sequencing Analysis in Early-Onset Primary Ovarian Insufficiency.
McGlacken-Byrne SM et al.·J Clin Endocrinol Metab
2025
Top 3 results · since 2015Search PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
No open access results found
Top 5 resultsSearch Europe PMC ↗
External Resources
Links to major genomics databases and tools