C2ORF80

Chr 2

chromosome 2 open reading frame 80

Also known as: GONDA1

The protein encoded by this gene is involved in mitochondrial function and cellular energy metabolism. Mutations cause autosomal recessive mitochondrial complex IV deficiency, presenting in infancy with severe neurodegeneration, hypotonia, and respiratory failure. This gene shows relatively low constraint against loss-of-function variants compared to other disease genes, consistent with its recessive inheritance pattern.

LOEUF 1.63
Clinical SummaryC2ORF80
Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.
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ClinVar Variants
28 unique Pathogenic / Likely Pathogenic· 11 VUS of 41 total submissions

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint
1.63LOEUF
pLI 0.000
Z-score -0.24
OE 1.07 (0.711.63)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint
-0.10Z-score
OE missense 1.03 (0.881.21)
109 obs / 106.1 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios
LoF OE1.07 (0.711.63)
00.351.4
Missense OE1.03 (0.881.21)
00.61.4
Synonymous OE1.28
01.21.6
LoF obs/exp: 15 / 14.0Missense obs/exp: 109 / 106.1Syn Z: -1.31

ClinVar Variant Classifications

41 submitted variants in ClinVar

Classification Summary

Pathogenic28
VUS11
28
Pathogenic
11
VUS

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
28
Likely Pathogenic
0
VUS
11
Likely Benign
0
Benign
0
Total39

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

C2ORF80 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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