C2ORF66

Chr 2

chromosome 2 open reading frame 66

Also known as: IIDS6411, UNQ6411

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
LOEUF 1.83
Clinical SummaryC2ORF66
Population Constraint (gnomAD)
Low constraint (pLI 0.01) — loss-of-function variants are relatively tolerated in the population.

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.83LOEUF
pLI 0.007
Z-score 0.11
OE 0.94 (0.411.83)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.28Z-score
OE missense 0.90 (0.721.13)
54 obs / 60.2 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.94 (0.411.83)
00.351.4
Missense OE?0.90 (0.721.13)
00.61.4
Synonymous OE?0.78
01.21.6
LoF obs/exp: 3 / 3.2Missense obs/exp: 54 / 60.2Syn Z: 0.84

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

C2ORF66 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →