C2ORF66
Chr 2chromosome 2 open reading frame 66
Also known as: IIDS6411, UNQ6411
C2ORF66 encodes a protein predicted to be located in the extracellular region, though its specific function remains unclear. The gene shows low constraint against loss-of-function variants (pLI = 0.007, LOEUF = 1.83), suggesting tolerance to functional disruption. No established disease associations have been reported for mutations in this gene.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
C2ORF66 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools