C2CD2
Chr 21C2 calcium dependent domain containing 2
Also known as: C21orf25, C21orf258, TMEM24L
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.68LOEUF
pLI 0.000
Z-score 2.98
OE 0.43 (0.29–0.68)
Typical tolerance to LoF variation
Missense Constraint?
1.21Z-score
OE missense 0.83 (0.76–0.91)
336 obs / 404.5 exp
Mild missense constraint
Observed / Expected Ratios?
LoF OE?0.43 (0.29–0.68)
0≤0.351.4
Missense OE?0.83 (0.76–0.91)
0≤0.61.4
Synonymous OE?1.07
0≤1.21.6
LoF obs/exp: 14 / 32.2Missense obs/exp: 336 / 404.5Syn Z: -0.77
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
C2CD2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools