C1ORF198
Chr 1chromosome 1 open reading frame 198
The protein encoded by this gene localizes to the cytosol, but its specific molecular function remains unclear. This gene is highly constrained against loss-of-function variants (pLI = 0.0006), suggesting it plays an important biological role, though associated diseases have not yet been definitively established. Further research is needed to determine the clinical significance of variants in this gene.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
C1ORF198 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools