C1ORF141
Chr 1chromosome 1 open reading frame 141
Clinical Summary— C1ORF141
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Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.
Some data sources returned errors (1)
ncbi: Error: NCBI fetch failed: 429 https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Tolerant — LoF & missense variants common in population
LoF Constraint
1.20LOEUF
pLI 0.003
Z-score 1.17
OE 0.57 (0.30–1.20)
Highly tolerant — LoF variants common in population
Missense Constraint
0.05Z-score
OE missense 0.99 (0.88–1.12)
188 obs / 190.0 exp
Mild missense constraint
Observed / Expected Ratios
LoF OE0.57 (0.30–1.20)
0≤0.351.4
Missense OE0.99 (0.88–1.12)
0≤0.61.4
Synonymous OE1.09
0≤1.21.6
LoF obs/exp: 5 / 8.7Missense obs/exp: 188 / 190.0Syn Z: -0.61
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
C1ORF141 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →Clinical Literature
Open Research Assistant →Landmark / reviewRecent case evidence
Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
GWAS identifies genetic loci, lifestyle factors and circulating biomarkers that are risk factors for sarcoidosis
Yuan S et al.·Nat Commun
2025
Kernel-based genetic association analysis for microbiome phenotypes identifies host genetic drivers of beta-diversity
Liu H et al.·Microbiome
2023
Genome-wide association for sarcoidosis identifies novel risk loci and genetic heritability in African and European ancestries: a meta-analysis from the Finngen, Million Veteran Program, UK Biobank, and Biobank Japan datasets
Ricci A et al.·Orphanet J Rare Dis
2025
TANC1 methylation as a novel biomarker for the diagnosis of patients with anti-tuberculosis drug-induced liver injury
Wu D et al.·Sci Rep
2021Cohort
CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice
Oyama Y et al.·Asian J Androl
2022
Top 5 full-text resultsSearch PubTator3 ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Variants in IL23R-C1orf141 and ADO-ZNF365-EGR2 are associated with susceptibility to Vogt-Koyanagi-Harada disease in Japanese population.
Sakono T et al.·PLoS One
2020Open Access
Top 5 resultsSearch Europe PMC ↗
External Resources
Links to major genomics databases and tools