C16ORF92
Chr 16fertilization-influencing membrane protein 1
Also known as: C16orf92, FIMP
The protein is predicted to be involved in sperm-oocyte fusion during fertilization and localizes to the plasma membrane. Currently, no well-established human diseases have been definitively linked to mutations in this gene. The gene shows low constraint against loss-of-function variants (pLI = 0.03, LOEUF = 1.26), suggesting tolerance to functional disruption.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
ClinVar Variant Classifications
167 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | — | — | — | — | 123 |
Likely Pathogenic | — | — | — | — | 40 |
VUS | — | — | — | — | 4 |
Likely Benign | — | — | — | — | 0 |
Benign | — | — | — | — | 0 |
| Total | — | 167 | |||
Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
C16ORF92 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools