C16ORF46
Chr 16chromosome 16 open reading frame 46
The protein encoded by this gene localizes to the cytosol and nucleoplasm, though its specific molecular function remains unclear. This gene is highly constrained against loss-of-function variants (pLI ~0), suggesting that complete loss of function is likely incompatible with normal development or survival. However, no definitive disease associations have been established for C16ORF46 mutations in current clinical literature.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Tolerant to missense variation
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
C16ORF46 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools