C11ORF97

Chr 11

chromosome 11 open reading frame 97

Also known as: LINC01171

NCBI Gene: 643037 ENSG00000257057 UniProt: A0A1B0GVM6

Predicted to be located in ciliary basal body. Predicted to be active in ciliary base. [provided by Alliance of Genome Resources, Jul 2025]

Research

Predicted to be located in ciliary basal body. Predicted to be active in ciliary base. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

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LOEUF

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Mechanism

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

Background carrier burden — how many people carry a rare variant somewhere in C11ORF97?

gnomAD v4 · ~692k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 500

181 rare PASS variants

Rare truncating (LoF)

1 in 2,000

39 rare PASS variants

Rare synonymous (reference)

1 in 1,600

68 rare PASS variants

Rare missense and truncating variants are carried at similar rates in C11ORF97; this gene does not show strong loss-of-function constraint by this measure. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~539k	1 in 660	1 in 2,100
South Asian	~40k	1 in 300	1 in 1,500
Remaining (unassigned)	~29k	1 in 450	1 in 3,100
African / African American	~21k	1 in 240	1 in 1,000
East Asian	~18k	1 in 460	1 in 1,000
Admixed American	~18k	1 in 250	≈ 1 in 3,800
European (Finnish)	~17k	1 in 270	1 in 2,100
Ashkenazi Jewish	~13k	1 in 330	1 in 2,500
Middle Eastern	~2,848	1 in 160	≈ 1 in 1,500

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.

Exome coverage (gnomAD): 1 of 4 coding exons well covered in gnomAD exomes; exons 1, 2, 4 marginal. Genomes: all 4.? see exons ↓