C11ORF65

Chr 11

chromosome 11 open reading frame 65

Also known as: MFI

Predicted to be involved in negative regulation of mitochondrial fission and negative regulation of protein targeting to mitochondrion. Predicted to be located in cytosol and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
1
Pubs (1 yr)
P/LP submissions
P/LP missense
1.75
LOEUF
Mechanism
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.75LOEUF
pLI 0.000
Z-score -0.80
OE 1.22 (0.851.75)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.37Z-score
OE missense 0.92 (0.801.05)
148 obs / 161.2 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?1.22 (0.851.75)
00.351.4
Missense OE?0.92 (0.801.05)
00.61.4
Synonymous OE?0.84
01.21.6
LoF obs/exp: 19 / 15.6Missense obs/exp: 148 / 161.2Syn Z: 0.90

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

C11ORF65 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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