C10ORF55
Chr 10ADchromosome 10 putative open reading frame 55
Primary Disease Associations & Inheritance
{Alzheimer disease, late-onset, susceptibility to}MIM #104300
AD
Quebec platelet disorderMIM #601709
AD
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.94LOEUF
pLI 0.014
Z-score -0.80
OE 1.83 (0.50–1.94)
Highly tolerant — LoF variants common in population
Missense Constraint?
0.42Z-score
OE missense 0.87 (0.72–1.06)
74 obs / 85.0 exp
Mild missense constraint
Observed / Expected Ratios?
LoF OE?1.83 (0.50–1.94)
0≤0.351.4
Missense OE?0.87 (0.72–1.06)
0≤0.61.4
Synonymous OE?0.70
0≤1.21.6
LoF obs/exp: 2 / 1.1Missense obs/exp: 74 / 85.0Syn Z: 1.38
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
C10ORF55 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools