C10ORF105
Chr 10chromosome 10 open reading frame 105
The C10ORF105 protein is predicted to be located in cellular membranes, though its specific function remains unclear. Mutations in this gene have not been definitively associated with any recognized pediatric neurological disorders. The gene shows low constraint against loss-of-function variants (pLI 0.08, LOEUF 1.9), suggesting it may be tolerant to disruption.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Tolerant to missense variation
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
C10ORF105 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools