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BRNRS

Chr XXLR

monoamine oxidase A

Also known as: BRNRS, MAO-A

NCBI Gene: 4128 OMIM: 300615

This gene encodes a mitochondrial enzyme that catalyzes the oxidative deamination of neurotransmitters including dopamine, norepinephrine, and serotonin. Mutations cause Brunner syndrome, an X-linked recessive disorder characterized by intellectual disability and behavioral abnormalities including impulsive aggression. The gene has also been associated with various other psychiatric and behavioral disorders.

GeneReviews OMIM ResearchSummary from RefSeq, OMIM

This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

GeneReviews OMIM ResearchGenerating clinical summary…