BRD10
Chr 9bromodomain containing 10
Also known as: KIAA2026
BRD10 encodes a bromodomain-containing protein predicted to be located in the nucleus, likely involved in chromatin regulation and gene transcription. Mutations in BRD10 cause neurodevelopmental disorders with intellectual disability, often accompanied by seizures and developmental delays. The gene follows autosomal dominant inheritance and shows high constraint against loss-of-function variants (LOEUF 0.336), indicating intolerance to protein-truncating mutations.
Some data sources returned errors (1)
omim: Error: OMIM fetch failed: 429
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly LoF-intolerant (top ~10% of genes)
Tolerant to missense variation
ClinVar Variant Classifications
413 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 0 | 0 | 51 | 0 | 51 |
Likely Pathogenic | 0 | 0 | 5 | 0 | 5 |
VUS | 0 | 323 | 4 | 0 | 327 |
Likely Benign | 0 | 13 | 0 | 2 | 15 |
Benign | 0 | 0 | 0 | 0 | 0 |
Conflicting | — | 1 | |||
| Total | 0 | 336 | 60 | 2 | 399 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
BRD10 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools