BRD10
Chr 9bromodomain containing 10
Also known as: KIAA2026
Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
ResearchGenerating clinical summary…
LOEUF 0.34
Clinical Summary— BRD10
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Population Constraint (gnomAD)
Moderately constrained gene (pLI 0.66) — some intolerance to loss-of-function variants.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
LoF intolerant — likely haploinsufficient
LoF Constraint?
0.34LOEUF
pLI 0.659
Z-score 5.87
OE 0.22 (0.14–0.34)
Highly LoF-intolerant (top ~10% of genes)
Missense Constraint?
-4.33Z-score
OE missense 1.38 (1.32–1.44)
1447 obs / 1052.1 exp
Tolerant to missense variation
Observed / Expected Ratios?
LoF OE?0.22 (0.14–0.34)
0≤0.351.4
Missense OE?1.38 (1.32–1.44)
0≤0.61.4
Synonymous OE?1.46
0≤1.21.6
LoF obs/exp: 14 / 65.0Missense obs/exp: 1447 / 1052.1Syn Z: -7.12
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
BRD10 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools