BPY2B
Chr Ybasic charge Y-linked 2B
Also known as: VCY2B
The BPY2B protein is expressed specifically in testis and interacts with ubiquitin protein ligase E3A, functioning in male germ cell development. Mutations in this Y chromosome gene are associated with male infertility. This gene follows Y-linked inheritance, being passed from father to son.
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
111 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | — | — | — | — | 75 |
Likely Pathogenic | — | — | — | — | 5 |
VUS | — | — | — | — | 21 |
Likely Benign | — | — | — | — | 7 |
Benign | — | — | — | — | 3 |
| Total | — | 111 | |||
Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
BPY2B · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools