BPY2
Chr Ybasic charge Y-linked 2
Also known as: BPY2A, VCY2, VCY2A
The BPY2 protein is expressed specifically in testis and interacts with ubiquitin protein ligase E3A, functioning in male germ cell development. Mutations in this Y chromosome gene are associated with male infertility. This gene shows Y-linked inheritance, being passed from father to son.
Clinical Summary— BPY2
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
BPY2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →Clinical Literature
Open Research Assistant →Landmark / reviewRecent case evidence
Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
Fast Catalysis at Low Overpotential: Designing Efficient Dicationic Re(bpy2+)(CO)3I Electrocatalysts for CO2 Reduction.
Rotundo L et al.·J Am Chem Soc
2024
Band Structure Optimized by Electron-Acceptor Cations for Sensitive Perovskite Single Crystal Self-Powered Photodetectors.
Huang YH et al.·Small
2023
Directional Ring Translocation in a pH- and Redox-Driven Tristable [2]Rotaxane.
Andreoni L et al.·Angew Chem Int Ed Engl
2024
Cationic Covalent Organic Framework as an Ion Exchange Material for Efficient Adsorptive Separation of Biomolecules.
Mosleh I et al.·ACS Appl Mater Interfaces
2021
Top 5 full-text resultsSearch PubTator3 ↗
Key Publications
Landmark & review papers · by relevance
Cytogenetics investigation in 151 Brazilian infertile male patients and genomic analysis in selected cases: experience of 14 years in a public genetic service.
Adriano MRG et al.·BMC Res Notes
2024Cohort
Comprehensive copy number analysis of Y chromosome-linked loci for detection of structural variations and diagnosis of male infertility.
Chen S et al.·J Hum Genet
2022
A common 1.6 mb Y-chromosomal inversion predisposes to subsequent deletions and severe spermatogenic failure in humans.
Hallast P et al.·Elife
2021
Yq Microdeletion in a Patient with VACTERL Association and Shawl Scrotum with Bifid Scrotum: A Real Pathogenetic Association or a Coincidence?
Tumini S et al.·Cytogenet Genome Res
2019Case report
Top 5 results · since 2015Search PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Theoretical study of water oxidation by the ruthenium blue dimer. II. Proton relay chain mechanism for the step [bpy2(HOO)Ru(IV)ORu(IV)(OH)bpy2]4+ → [bpy2(O2(–))Ru(IV)ORu(III)(OH2)bpy2]4+.
Bianco R et al.·J Phys Chem B
2013Functional
Alu sequence variants of the BPY2 gene in proven fertile and infertile men with Sertoli cell-only phenotype.
Choi J et al.·Int J Urol
2007
The human Y chromosome genes BPY2, CDY1 and DAZ are not essential for sustained fertility.
Saut N et al.·Mol Hum Reprod
2000
Top 5 resultsSearch Europe PMC ↗
External Resources
Links to major genomics databases and tools