BOD1L2

Chr 18

biorientation of chromosomes in cell division 1 like 2

Also known as: BOD1P, FAM44C

NCBI Gene: 284257ENSG00000228075UniProt: Q8IYS8

Predicted to be involved in cell division. Predicted to be located in centrosome; cytoplasm; and kinetochore. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
1
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.92
LOEUF
—
Mechanism
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.92LOEUF
pLI 0.076
Z-score -0.41
OE 1.56 (0.32–1.92)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.17Z-score
OE missense 0.95 (0.80–1.13)
92 obs / 96.6 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?1.56 (0.32–1.92)
0≤0.351.4
Missense OE?0.95 (0.80–1.13)
0≤0.61.4
Synonymous OE?1.07
0≤1.21.6
LoF obs/exp: 1 / 0.6Missense obs/exp: 92 / 96.6Syn Z: -0.38

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

BOD1L2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients