BOD1L2
Chr 18biorientation of chromosomes in cell division 1 like 2
Also known as: BOD1P, FAM44C
The protein is predicted to function in cell division and may be involved in proper chromosome alignment during mitosis by detecting or correcting improper chromosome attachments to the mitotic spindle. Currently, no human diseases have been definitively associated with BOD1L2 mutations in the medical literature. The gene shows low constraint against loss-of-function variants (pLI = 0.08, LOEUF = 1.9), suggesting it may tolerate genetic variation better than highly disease-associated genes.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
ClinVar Variant Classifications
71 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | — | — | — | — | 63 |
Likely Pathogenic | — | — | — | — | 2 |
VUS | — | — | — | — | 6 |
Likely Benign | — | — | — | — | 0 |
Benign | — | — | — | — | 0 |
| Total | — | 71 | |||
Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
BOD1L2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools