BGLAP

Chr 1

bone gamma-carboxyglutamate protein

Also known as: BGP, OC, OCN

NCBI Gene: 632ENSG00000242252UniProt: P02818

This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]

ResearchGenerating clinical summary…
9
Active trials
126
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.95
LOEUF
DN
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.95LOEUF
pLI 0.000
Z-score -1.58
OE 1.76 (0.96–1.95)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.33Z-score
OE missense 0.88 (0.71–1.10)
56 obs / 63.5 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?1.76 (0.96–1.95)
0≤0.351.4
Missense OE?0.88 (0.71–1.10)
0≤0.61.4
Synonymous OE?1.25
0≤1.21.6
LoF obs/exp: 9 / 5.1Missense obs/exp: 56 / 63.5Syn Z: -1.06

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

BGLAP · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov
Osteoporosis, Postmenopausal

Vascular Function, Sarcopenia and Pain in Postmenopausal Osteoporosis

RECRUITING
NCT05228262Phase NAUniversity Hospital, Clermont-FerrandStarted 2022-02-15
Cohort follow-up
CAH - Congenital Adrenal Hyperplasia

Hydrocortisone Modified-release in Adults: Real-world Monitoring of Longitudinal Outcomes in coNgenital Adrenal hYperplasia

NOT YET RECRUITING
NCT07622030IRCCS San RaffaeleStarted 2026-07-31
Osteoporosis，Neurological Disorders

Beijing Osteoporosis With Neurological Disorders in Epigenetic Changes Study

ACTIVE NOT RECRUITING
NCT03401619Peking University Third HospitalStarted 2017-09-21
Exercise，Nutrition，Bisphosphonates，Statins，Calcitonin,Vitamin D，et al.
Klinefelter Syndrome

Klinefelter Syndrome and Testosterone Treatment in Puberty

RECRUITING
NCT06294990Phase PHASE4Lise AksglædeStarted 2024-08-15
Testosterone gelPlacebo
Primary Osteoporosis

Vitamin D Status and Multi-Omics Profiles in Primary Osteoporosis

RECRUITING
NCT07296471Dr. Li ChenStarted 2025-11-11
Alveolar Bone Loss Associated Chronic Periodontitis

Clinical Efficacy of 1% Metformin and Alendronate Gel in Adjunct to Fibrin in Chronic Periodontitis

ACTIVE NOT RECRUITING
NCT06856369Phase PHASE4Bahria UniversityStarted 2025-01-22
Platelet rich fibrinMetformin hydrochloride powderalendronate sodium powder
Inflammatory Bowel DiseaseCrohn Disease

Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease

RECRUITING
NCT04508088Massachusetts General HospitalStarted 2020-09-10
Coronal T1 weighted spin echo imagesSpin-lattice relaxation (T1)Magnetic resonance spectroscopy
Obesity, Morbid

Different Limb Lengths in Gastric Bypass Surgery (SLIM) - Part 3: Metabolism and Inflammation

ACTIVE NOT RECRUITING
NCT05471037Phase NAUniversity Hospital, Basel, SwitzerlandStarted 2022-08-01
Long Biliopancreatic Limb LRYGBShort Biliopancreatic Limb LRYGB
OsteoporosisOsteopenia

A Pilot Study of Vitamin K2 (Menaquinone-7, Soloways ™) in Patients With Osteopenia/Osteoporosis Carrying a VDR Gene Variant

RECRUITING
NCT06867952Phase NAS.LAB (SOLOWAYS)Started 2024-05-03
Vitamin K2 plus vitamin D3Vitamin K2 plus vitamin D3

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients