BANCR

Chr 9

BRAF-activated non-protein coding RNA

Also known as: LINC00586

NCBI Gene: 100885775ENSG00000278910

This gene produces a long non-coding RNA that plays a role in tumor progression and epithelial to mesenchymal transition. This transcript acts through the MAP kinase signaling pathway. [provided by RefSeq, Dec 2017]

59
ClinVar variants
41
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— BANCR
📋
ClinVar Variants
41 Pathogenic / Likely Pathogenic· 12 VUS of 59 total submissions
Some data sources returned errors (1)

gnomad: Error: Gene not found

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

59 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic33
Likely Pathogenic8
VUS12
Likely Benign2
33
Pathogenic
8
Likely Pathogenic
12
VUS
2
Likely Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————33
Likely Pathogenic
————8
VUS
————12
Likely Benign
————2
Benign
————0
Total—55

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

BANCR · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Long non-coding RNAs in retinoblastoma.
Yang M et al.·Pathol Res Pract
2019Review
Long non-coding RNAs in melanoma.
Yu X et al.·Cell Prolif
2018Review
Over-expression of long noncoding RNA BANCR inhibits malignant phenotypes of human bladder cancer.
He A et al.·J Exp Clin Cancer Res
2016
Increased expression of LncRNA BANCR is associated with clinical progression and poor prognosis in gastric cancer.
Li L et al.·Biomed Pharmacother
2015
Long Non-coding RNAs and their Role in Metastasis.
Weidle UH et al.·Cancer Genomics Proteomics
2017Review
Long non-coding RNA BANCR regulates growth and metastasis and is associated with poor prognosis in retinoblastoma.
Su S et al.·Tumour Biol
2015
Increased expression of LncRNA BANCR and its prognostic significance in human epithelial ovarian cancer.
Xu X et al.·Eur J Gynaecol Oncol
2017
Long Non-Coding RNA BANCR Promotes Endometrial Cancer Cell Proliferation and Invasion by Regulating MMP2 and MMP1 via ERK/MAPK Signaling Pathway.
Wang D et al.·Cell Physiol Biochem
2016
Systematic Survey of the Regulatory Networks of the Long Noncoding RNA BANCR in Cervical Cancer Cells.
Wang B et al.·J Proteome Res
2022
Elevated BANCR expression levels have different effects on papillary thyroid carcinoma progression depending on the presence of the BRAFV600E mutation.
Stojanović S et al.·Eur J Surg Oncol
2020
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Retraction Note: Long non-coding RNA BANCR indicates poor prognosis for breast cancer and promotes cell proliferation and invasion.
Lou KX et al.·Eur Rev Med Pharmacol Sci
2025
lncRNA BANCR Suppresses Cell Viability and Invasion and Promotes Apoptosis in Non-Small-Cell Lung Cancer Cells in vitro and in vivo [Retraction].
·Cancer Manag Res
2025🔓 Open Access
LncRNA BANCR/miR-15a/MAPK1 Induces Apoptosis and Increases Proliferation of Vascular Smooth Muscle Cells in Aortic Dissection by Enhancing MMP2 Expression.
Zheng Z et al.·Cell Biochem Biophys
2025
BANCR-containing extracellular vesicles enhance breast cancer resistance.
Song X et al.·J Biol Chem
2025🔓 Open Access
Effect of long-stranded non-coding RNA-BANCR on the progression of thyroid papillary carcinoma and its mechanism.
Yu J et al.·Discov Oncol
2025🔓 Open AccessFunctional
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools