BAG1
Chr 9BAG cochaperone 1
Also known as: BAG-1, HAP, RAP46
BAG1 encodes a co-chaperone protein that facilitates HSP70/HSC70 chaperone function by promoting nucleotide exchange and client protein release, while also enhancing the anti-apoptotic effects of BCL2. Mutations in BAG1 cause autosomal dominant myofibrillar myopathy with early adult onset, characterized by progressive muscle weakness and cardiac involvement. The gene shows very low constraint against loss-of-function variants (pLI near 0), suggesting tolerance to such mutations.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Tolerant to missense variation
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
BAG1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
Effect of Transcranial Alternative Current Stimulation at Alpha Frequency (α-tACS) on Stressed Healthy Subjects
RECRUITINGAn AAV Gene Therapy Trial of AFTX-201 in Adults With BAG3-Associated Dilated Cardiomyopathy (DCM)
NOT YET RECRUITINGA Phase 1 AAV Gene Therapy Trial Evaluating Safety and Preliminary Efficacy of RP-A701 in Subjects With BAG3 Dilated Cardiomyopathy
RECRUITINGReality-monitoring & Stress
RECRUITINGExternal Resources
Links to major genomics databases and tools