AUNIP
Chr 1aurora kinase A and ninein interacting protein
Also known as: AIBP, C1orf135
The AUNIP protein binds damaged DNA and promotes homologous recombination repair while inhibiting non-homologous end joining, and is also required for proper spindle organization during cell division. The gene shows minimal constraint against loss-of-function variants (pLI near 0, LOEUF 1.58), suggesting that heterozygous loss-of-function may be tolerated. Disease associations and inheritance patterns for AUNIP mutations have not been established in the provided data.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
ClinVar Variant Classifications
72 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 0 | 0 | 5 | 0 | 5 |
Likely Pathogenic | 0 | 0 | 0 | 0 | 0 |
VUS | 0 | 53 | 6 | 0 | 59 |
Likely Benign | 1 | 1 | 0 | 0 | 2 |
Benign | 0 | 0 | 0 | 0 | 0 |
| Total | 1 | 54 | 11 | 0 | 66 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
AUNIP · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools