ASB7
Chr 15ankyrin repeat and SOCS box containing 7
ASB7 encodes a substrate-recognition component of an E3 ubiquitin ligase complex that targets specific proteins for degradation, regulating chromatin modifications and cell cycle progression. The gene is highly constrained against loss-of-function variants (pLI 0.98, LOEUF 0.28), but no established Mendelian disorders have been definitively linked to ASB7 mutations in current clinical practice.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly LoF-intolerant (top ~10% of genes)
Highly missense-constrained (top ~0.1%)
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
ASB7 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools