ARPC4-TTLL3

Chr 3

ARPC4-TTLL3 readthrough

This locus represents naturally occurring read-through transcription between the neighboring ARPC4 (actin related protein 2/3 complex, subunit 4) and TTLL3 (tubulin tyrosine ligase-like family, member 3) genes. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Nov 2010]

ResearchGenerating clinical summary…
0
Active trials
0
Pubs (1 yr)
P/LP submissions
P/LP missense
1.08
LOEUF
Mechanism
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.08LOEUF
pLI 0.000
Z-score 1.21
OE 0.77 (0.551.08)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
1.00Z-score
OE missense 0.86 (0.780.94)
334 obs / 389.4 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.77 (0.551.08)
00.351.4
Missense OE?0.86 (0.780.94)
00.61.4
Synonymous OE?0.85
01.21.6
LoF obs/exp: 24 / 31.3Missense obs/exp: 334 / 389.4Syn Z: 1.45

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

ARPC4-TTLL3 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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