ARMH3

Chr 10

armadillo like helical domain containing 3

Also known as: C10orf76, DGARM

NCBI Gene: 79591ENSG00000120029UniProt: Q5T2E6OMIM: 620867

Involved in regulation of Golgi organization. Located in Golgi membrane and cytosol. [provided by Alliance of Genome Resources, Jul 2025]

OMIMResearchGenerating clinical summary…
0
Active trials
3
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.57
LOEUF
GOF
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Moderate LoF intolerance
LoF Constraint?
0.57LOEUF
pLI 0.000
Z-score 3.82
OE 0.38 (0.26–0.57)
Moderately constrained

More LoF-intolerant than ~75% of genes

Missense Constraint?
2.01Z-score
OE missense 0.71 (0.64–0.79)
271 obs / 381.7 exp
Mild constraint

Moderately missense-constrained (top ~2.5%)

Observed / Expected Ratios?
LoF OE?0.38 (0.26–0.57)
0≤0.351.4
Missense OE?0.71 (0.64–0.79)
0≤0.61.4
Synonymous OE?0.92
0≤1.21.6
LoF obs/exp: 17 / 44.5Missense obs/exp: 271 / 381.7Syn Z: 0.69

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

ARMH3 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients