ARMCX3
Chr Xarmadillo repeat containing X-linked 3
Also known as: ALEX3, GASP6, dJ545K15.2
ARMCX3 encodes a protein that regulates mitochondrial transport and aggregation in axons by linking mitochondria to the TRAK2-kinesin motor complex, and enhances SOX10-mediated transactivation of neuronal acetylcholine receptor subunit genes. Mutations cause X-linked intellectual disability with variable neurological features. This X-linked gene follows typical X-linked inheritance patterns with affected males and carrier females who may have milder manifestations.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
ARMCX3 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools