ARHGAP35

The protein functions as a Rho GTPase-activating protein that regulates cell adhesion, migration, and morphogenesis, playing critical roles in retinal development, neural tube fusion, cerebral hemisphere midline fusion, and axon outgrowth and guidance. Mutations cause neurodevelopmental disorders with intellectual disability, developmental delay, and structural brain abnormalities, inherited in an autosomal dominant pattern. The gene is extremely intolerant to loss-of-function variants, indicating that proper protein dosage is critical for normal neurodevelopment.