ARHGAP32

Chr 11

Rho GTPase activating protein 32

Also known as: GC-GAP, GRIT, PX-RICS, RICS, p200RhoGAP, p250GAP

NCBI Gene: 9743ENSG00000134909UniProt: A7KAX9

RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008]

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0
Active trials
4
Pubs (1 yr)
0
P/LP submissions
—
P/LP missense
0.25
LOEUF· LoF intol.
LOF
Mechanism· predicted
Clinical Summary— ARHGAP32
⚡
Population Constraint (gnomAD)
Highly constrained gene — heterozygous loss-of-function variants are very rare in the population (pLI 1.00). One damaged copy is likely sufficient to cause disease.
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Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
LoF intolerant — likely haploinsufficient
LoF Constraint
0.25LOEUF
pLI 1.000
Z-score 7.02
OE 0.16 (0.10–0.25)
Highly constrained

Highly LoF-intolerant (top ~10% of genes)

Missense Constraint
1.81Z-score
OE missense 0.85 (0.81–0.90)
976 obs / 1148.3 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios
LoF OE0.16 (0.10–0.25)
0≤0.351.4
Missense OE0.85 (0.81–0.90)
0≤0.61.4
Synonymous OE0.98
0≤1.21.6
LoF obs/exp: 13 / 81.3Missense obs/exp: 976 / 1148.3Syn Z: 0.37
DN
0.4090th %ile
GOF
0.4678th %ile
LOF
0.73top 10%

The highest-scoring mechanism for this gene is loss-of-function (haploinsufficiency).

LOFprediction above median · LOEUF 0.25

Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312. Mechanism ranking also informed by gnomAD constraint, ClinVar, and ClinGen data.

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

ARHGAP32 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
PubTator3
Circ_ARHGAP32 acts as miR-665 sponge to upregulate FGF2 to promote ox-LDL induced vascular smooth muscle cells proliferation and migration.
Wang Y et al.·Clin Hemorheol Microcirc
2022
The Lipid-binding PX Domain of RRC-1 (ARHGAP32/33) is Required for Optimal Assembly and Function of Integrin Adhesion Complexes at the Muscle Cell Boundary in C. elegans
Sagadiev S et al.·bioRxiv
2025
Transcriptomic Analysis Reveals the Effects of miR-122 Overexpression in the Liver of Qingyuan Partridge Chickens
Luo X et al.·Animals (Basel)
2024
Quantitative proteomics of dorsolateral prefrontal cortex reveals an early pattern of synaptic dysmaturation in children with idiopathic autism.
Fatemi SH et al.·Cereb Cortex
2024
Hippocampal proteomic changes in high-fat diet-induced obese mice associated with memory decline.
Lu P et al.·J Nutr Biochem
2023
Top 5 full-text resultsSearch PubTator3 ↗
Key Publications
Landmark & review papers · by relevance
PubMed
Top 5 results · since 2015Search PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients