ANXA10

Chr 4

annexin A10

Also known as: ANX14

NCBI Gene: 11199ENSG00000109511UniProt: Q9UJ72OMIM: 608008

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]

OMIMResearchGenerating clinical summary…
0
Active trials
14
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.24
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.24LOEUF
pLI 0.000
Z-score 0.61
OE 0.87 (0.62–1.24)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.40Z-score
OE missense 0.92 (0.80–1.04)
160 obs / 174.8 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.87 (0.62–1.24)
0≤0.351.4
Missense OE?0.92 (0.80–1.04)
0≤0.61.4
Synonymous OE?0.95
0≤1.21.6
LoF obs/exp: 22 / 25.3Missense obs/exp: 160 / 174.8Syn Z: 0.31

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

ANXA10 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients