ANP32C
Chr 4acidic nuclear phosphoprotein 32 family member C, pseudogene
Also known as: ANP32C, PP32R1
ANP32C encodes a protein that binds histones and regulates apoptosis, with predicted roles in nucleocytoplasmic transport and nuclear function. Currently, no established human diseases have been definitively linked to ANP32C mutations. The inheritance pattern and clinical phenotype remain to be determined as pathogenic variants are identified and characterized.
Some data sources returned errors (2)
ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/ANP32C?content-type=application/json&expand=1
gnomad: Error: Gene not found
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
53 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | — | — | — | — | 42 |
Likely Pathogenic | — | — | — | — | 2 |
VUS | — | — | — | — | 7 |
Likely Benign | — | — | — | — | 2 |
Benign | — | — | — | — | 0 |
| Total | — | 53 | |||
Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
ANP32C · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools