ANO2
Chr 12anoctamin 2
Also known as: C12orf3, TMEM16B
ANO2 belongs to a family of calcium-activated chloride channels (CaCCs) (reviewed by Hartzell et al., 2009 [PubMed 19015192]).[supplied by OMIM, Jan 2011]
ResearchGenerating clinical summary…
Some data sources returned errors (1)
omim: Error: OMIM fetch failed: 429
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.96LOEUF
pLI 0.000
Z-score 1.79
OE 0.74 (0.58–0.96)
Typical tolerance to LoF variation
Missense Constraint?
-0.01Z-score
OE missense 1.00 (0.93–1.07)
568 obs / 567.1 exp
Tolerant to missense variation
Observed / Expected Ratios?
LoF OE?0.74 (0.58–0.96)
0≤0.351.4
Missense OE?1.00 (0.93–1.07)
0≤0.61.4
Synonymous OE?0.97
0≤1.21.6
LoF obs/exp: 42 / 56.5Missense obs/exp: 568 / 567.1Syn Z: 0.41
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
ANO2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools