ANKS3
Chr 16ankyrin repeat and sterile alpha motif domain containing 3
Predicted to be located in cytoplasm. Predicted to be active in cilium. [provided by Alliance of Genome Resources, Jul 2025]
ResearchGenerating clinical summary…
Some data sources returned errors (1)
omim: Error: OMIM fetch failed: 429
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.73LOEUF
pLI 0.000
Z-score 2.83
OE 0.48 (0.33–0.73)
Typical tolerance to LoF variation
Missense Constraint?
-1.76Z-score
OE missense 1.25 (1.16–1.34)
497 obs / 398.3 exp
Tolerant to missense variation
Observed / Expected Ratios?
LoF OE?0.48 (0.33–0.73)
0≤0.351.4
Missense OE?1.25 (1.16–1.34)
0≤0.61.4
Synonymous OE?1.38
0≤1.21.6
LoF obs/exp: 17 / 35.1Missense obs/exp: 497 / 398.3Syn Z: -3.89
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
ANKS3 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools